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Peptides stimulate the pituitary gland and hypothalamus to produce its own HGH, so they keep the pituitarys negative feedback loop involved, which keeps the pituitary gland from burning out

The first generation of GLP-1 therapies exhibit reduced susceptibility to enzymatic degradation, while providing effective glucose control, improved -cell function, body weight loss and decreased systolic blood pressure in patients with T2D (Meier, 2012) The newly developed incretin mimetics, including albiglutide, dulaglutide and semaglutide, are designed to have extended pharmacokinetic profiles and efficacy suitable once-weekly administration

References Andersen ES, Deacon CF, Holst JJ